A 77636 hydrochloride

Name: A 77636 hydrochloride
Brand: Tocris Bioscience
SKU: 1701

Tocris Bioscience, part of Bio-Techne | Catalog # 1701

Citations (8)

COA / SDS

Potent and selective D1-like agonist; orally active

Key Product Details

Chemical Name:	(1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride
Purity:	≥98%
Molecular Weight:	365.9 kDa

View Full Technical Details for A 77636 hydrochloride

Technical Data
Citations

Biological Activity for A 77636 hydrochloride

A 77636 hydrochloride is a potent and selective dopamine D₁-like receptor agonist (pEC₅₀ values are 8.97 and < 5 for D₁-like and D₂-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.

Technical Data for A 77636 hydrochloride

M. Wt	365.9 kDa
Formula	C₂₀H₂₇NO₃.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	145307-34-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 77636 hydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for A 77636 hydrochloride

References are publications that support the biological activity of the product.

K Minami, S Liu, Y Liu, A Chen, Q Wan, S Na, BY Li, N Matsuura, M Koizumi, Y Yin, L Gan, A Xu, J Li, H Nakshatri, H Yokota Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis Sci Rep, 2017;7(0):45686. 2017 PMID: 28374823
Acquas et al. The potent and selective DA D₁ receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat. Eur.J.Pharmacol., 1994;260:85 PMID: 7957630
Lewis et al. Homologous desensitization of the D_1A DA receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J.Pharmacol.Exp.Ther., 1998;286:345 PMID: 9655879
Kebabian et al. A-77636: a potent and selective DA D₁ receptor agonist with antiparkinsonian activity in marmosets. Eur.J.Pharmacol., 1992;229:203 PMID: 1362704