α-Bungarotoxin

Name: α-Bungarotoxin
Brand: Tocris Bioscience
SKU: 2133
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2133

(1)

Citations (81)

COA / SDS

Selective α7 nAChR antagonist

Key Product Details

Description:	Selective α7 nAChR antagonist
Alternative Names:	α-Bgtx,α-BuTX
Purity:	≥98% (HPLC)
Molecular Weight:	7984.14

View Full Technical Details for α-Bungarotoxin

Technical Data
Citations / Reviews (1)

Biological Activity for α-Bungarotoxin

α-Bungarotoxin is a neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC₅₀ values are 1.6 nM and > 3 μM respectively).

Technical Data for α-Bungarotoxin

M. Wt	7984.14
Formula	C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
Single Letter Sequence	IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG (Modifications: Disulfide bridges: 3-23, 16-44, 29-33, 48-59, 60-65)
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	11032-79-4
PubChem ID	90488742
InChi Key	NTCJKZSYQTZRQE-CSMGIIAWSA-N
Smiles	[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC2=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]3CCCN3C2=O)C(C)C)[C@@H](C)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC2=CNC=N2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(=O)NCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC2=CNC=N2)NC1=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for α-Bungarotoxin

References are publications that support the biological activity of the product.

Lopez Unmasking the functions of the chromaffin cell α₇ nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc.Natl.Acad.Sci.USA
Zhang Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels. Neuron 1994 PMID: 7507338

α-Bungarotoxin

Tocris Bioscience, part of Bio-Techne | Catalog # 2133

Key Product Details

Biological Activity for α-Bungarotoxin

Technical Data for α-Bungarotoxin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for α-Bungarotoxin

Product Documents for α-Bungarotoxin

COA

Certificate of Analysis

SDS

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