ABT 702 hydrochloride

Name: ABT 702 hydrochloride
Brand: Tocris Bioscience
SKU: 2372

Tocris Bioscience, part of Bio-Techne | Catalog # 2372

Citations (8)

COA / SDS

Adenosine kinase inhibitor; orally active

Key Product Details

Chemical Name:	5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine hydrochloride
Purity:	≥98%
Molecular Weight:	499.79 kDa

View Full Technical Details for ABT 702 hydrochloride

Technical Data
Citations

Biological Activity for ABT 702 hydrochloride

ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC₅₀ = 1.7 nM), selective over other sites of adenosine interaction (A₁, A_2A and A₃ receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

Technical Data for ABT 702 hydrochloride

M. Wt	499.79 kDa
Formula	C₂₂H₁₉N₆OBr.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	2624336-92-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABT 702 hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO

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References for ABT 702 hydrochloride

References are publications that support the biological activity of the product.

Kowaluk et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther., 2000;295:1165 PMID: 11082454
Lee et al. Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem., 2001;44:2133 PMID: 11405650
Jarvis et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive J.Pharmacol.Exp.Ther., 2000;295:1156 PMID: 11082453