AG 205

Name: AG 205
Brand: Tocris Bioscience
SKU: 6242

Tocris Bioscience, part of Bio-Techne | Catalog # 6242

Citations (3)

COA / SDS

Progesterone receptor membrane component 1 (Pgrmc1) ligand

Key Product Details

Description:	Progesterone receptor membrane component 1 (Pgrmc1) ligand
Chemical Name:	cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone
Purity:	≥97% (HPLC)
Molecular Weight:	454.98

View Full Technical Details for AG 205

Technical Data
Citations

Biological Activity for AG 205

AG 205 is a progesterone receptor membrane component 1 (Pgrmc1) ligand. Inhibits cell cycle progression and cell viability in cancer cell lines. Inhibits progesterone induced cytosolic Ca²⁺ increases in GnRH neurons in vitro.

Technical Data for AG 205

M. Wt	454.98
Formula	C₂₂H₂₃ClN₆OS
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	442656-02-2
PubChem ID	4240652
InChi Key	GJNBAISSZRNGTM-UHFFFAOYSA-N
Smiles	[H][C@@]12CCN(C)C[C@]1([H])C1=CC(C)=CC=C1N2C(=O)CSC1=NN=NN1C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AG 205

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.75	50

Preparing Stock Solutions for AG 205

The following data is based on the product molecular weight 454.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.40 mL	21.98 mL	43.96 mL
2.5 mM	0.88 mL	4.40 mL	8.79 mL
5 mM	0.44 mL	2.20 mL	4.40 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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References for AG 205

References are publications that support the biological activity of the product.

Bashour and Wray Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1. Endocrinology. 2012 PMID: 22822163
Yoshitani A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: combination of in silico screening and surface plasmon resonance measurements. Proteomics. 2005 PMID: 15798990
Ahmed Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. J.Pharmacol.Exp.Ther. 2010 PMID: 20164297