[Ala¹¹,D-Leu¹⁵]-Orexin B

Name: [Ala 11 ,D-Leu 15 ]-Orexin B
Brand: Tocris Bioscience
SKU: 2142

Tocris Bioscience, part of Bio-Techne | Catalog # 2142

Citations (10)

COA / SDS

Potent and selective OX2 agonist

Key Product Details

Description:	Potent and selective OX₂ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	2857.28

View Full Technical Details for [Ala¹¹,D-Leu¹⁵]-Orexin B

Technical Data
Citations

Biological Activity

[Ala¹¹,D-Leu¹⁵]-Orexin B is a highly potent and selective OX₂ receptor agonist; displays 400-fold selectivity over OX₁ receptors. EC₅₀ values are 0.13 and 52 nM for human OX₂ and OX₁ receptors respectively.

Technical Data

M. Wt	2857.28
Formula	C₁₂₀H₂₀₆N₄₄O₃₅S
Single Letter Sequence	RSGPPGLQGRAQRLLQASGNHAAGILTM (Modification: Leu-15 = D-Leu, Met-28 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	532932-99-3
PubChem ID	16201464
InChi Key	SURUUKNICBOUOQ-JNZZMZGCSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 0.3mg/ml in water

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References

References are publications that support the biological activity of the product.

Asahi Development of an orexin-2 receptor selective agonist, [Ala¹¹D-Leu¹⁵]orexin-B. Bioorg.Med.Chem.Lett. 2003 PMID: 12467628

[Ala¹¹,D-Leu¹⁵]-Orexin B

Tocris Bioscience, part of Bio-Techne | Catalog # 2142

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

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[Ala11,D-Leu15]-Orexin B

Tocris Bioscience, part of Bio-Techne | Catalog # 2142

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

[Ala¹¹,D-Leu¹⁵]-Orexin B