α-MSH

Name: α-MSH
Brand: Tocris Bioscience
SKU: 2584

Tocris Bioscience, part of Bio-Techne | Catalog # 2584

Citations (6)

COA / SDS

Endogenous melanocortin receptor agonist

Key Product Details

Purity:	≥95%
Molecular Weight:	1664.9 kDa

View Full Technical Details for α-MSH

Technical Data
Citations

Biological Activity for α-MSH

α-MSH is an endogenous melanocortin receptor agonist (K_i values are 0.12, 31, 660 and 5700 nM for MC₁, MC₃, MC₄ and MC₅ receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data for α-MSH

M. Wt	1664.9 kDa
Formula	C₇₇H₁₀₉N₂₁O₁₉S
Storage	Store at -20°C
Purity	≥95%
CAS Number	581-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-MSH

Solubility

Soluble Soluble to 0.60 mg/ml in water

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References for α-MSH

References are publications that support the biological activity of the product.

Wikber Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol., 1999;375:295 PMID: 10443584
Yamaoka-Tojo et al. Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med., 2006;45:429 PMID: 16679696
Mizusawa et al. Alpha-melanocyte stimulating hormone and oxyt. induced penile erections, and intracavernous pressure increases in the rat. J.Urol., 2002;167:757 PMID: 11792967