Amphotericin B

Name: Amphotericin B
Brand: Tocris Bioscience
SKU: 6930

Tocris Bioscience, part of Bio-Techne | Catalog # 6930

Citations (14)

COA / SDS

Forms monovalent ion channels in lipid bilyers; antifungal

Key Product Details

Description:	Forms monovalent ion channels in lipid bilyers; antifungal
Chemical Name:	(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Purity:	≥90% (HPLC)
Molecular Weight:	924.09

View Full Technical Details for Amphotericin B

Technical Data
Citations

Biological Activity for Amphotericin B

Amphotericin B forms nonselective monovalent ion channels within lipid bilayers. Amphotericin B binds ergosterol in the cell membrane. Antifungal and antiprotozoal.

For more information about how Amphotericin B may be used, see our protocol:

3D Culture of Lung Alveolar Cells

Technical Data for Amphotericin B

M. Wt	924.09
Formula	C₄₇H₇₃NO₁₇
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	1397-89-3
PubChem ID	5280965
InChi Key	APKFDSVGJQXUKY-INPOYWNPSA-N
Smiles	[H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amphotericin B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.48	20

Preparing Stock Solutions for Amphotericin B

The following data is based on the product molecular weight 924.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	5.41 mL	27.05 mL	54.11 mL
1 mM	1.08 mL	5.41 mL	10.82 mL
2 mM	0.54 mL	2.71 mL	5.41 mL
10 mM	0.11 mL	0.54 mL	1.08 mL

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References for Amphotericin B

References are publications that support the biological activity of the product.

Gallis Amphotericin B: 30 years of clinical experience. Rev.Infect.Dis. 1990 PMID: 2184499
Lewis Current concepts in antifungal pharmacology. Mayo Clin.Proc. 2011 PMID: 21803962
Muruglia Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia. Nature. 2019 PMID: 30867598