Amthamine dihydrobromide

Name: Amthamine dihydrobromide
Brand: Tocris Bioscience
SKU: 0668

Tocris Bioscience, part of Bio-Techne | Catalog # 0668

Citations (17)

COA / SDS

Highly selective standard H2 agonist

Key Product Details

Description:	Highly selective standard H₂ agonist
Chemical Name:	2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	319.06

View Full Technical Details for Amthamine dihydrobromide

Technical Data
Citations

Biological Activity for Amthamine dihydrobromide

Amthamine dihydrobromide is a highly selective H₂ agonist, slightly more potent than histamine itself. Only a weak antagonist at H₃ and has no activity at H₁ receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.

Technical Data for Amthamine dihydrobromide

M. Wt	319.06
Formula	C₆H₁₁N₃S.2HBr
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	142457-00-9
PubChem ID	16218912
InChi Key	XFXNNOPUDSFVJE-UHFFFAOYSA-N
Smiles	Br.Br.CC1=C(CCN)SC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amthamine dihydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	31.91	100

Preparing Stock Solutions for Amthamine dihydrobromide

The following data is based on the product molecular weight 319.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.67 mL	31.34 mL
5 mM	0.63 mL	3.13 mL	6.27 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Amthamine dihydrobromide

References are publications that support the biological activity of the product.

Poli In vitro cardiac pharmacology of the new histamine H₂ receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 1993 PMID: 8147269
Eriks Histamine H₂-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 1992 PMID: 1507209
Jarajapu Histamine decreases myogenic tone in rat cerebral arteries by H₂-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 2006 PMID: 16920098
Coruzzi The new potent and selective histamine H₂ receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 8377843