AR-C 141990 hydrochloride

Name: AR-C 141990 hydrochloride
Brand: Tocris Bioscience
SKU: 5658

Tocris Bioscience, part of Bio-Techne | Catalog # 5658

Citations (1)

COA / SDS

MCT1 inhibitor

Key Product Details

Description:	MCT1 inhibitor
Chemical Name:	5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	529.05

View Full Technical Details for AR-C 141990 hydrochloride

Technical Data
Citations

Biological Activity for AR-C 141990 hydrochloride

AR-C 141990 hydrochloride is a monocarboxylate transporter (MCT1) inhibitor (pK_i = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.

Technical Data for AR-C 141990 hydrochloride

M. Wt	529.05
Formula	C₂₆H₂₈N₄O₄S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250019-94-2
PubChem ID	129316183
InChi Key	NFFGLQDNUHBVEY-UNTBIKODSA-N
Smiles	O=C(N1C[C@H](O)CC1)C2=C(CC3=C4C(C=CC=C4)=NC=C3)SC(N5CC(C)C)=C2C(N(C)C5=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AR-C 141990 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	49.26	100
	DMSO	49.26	100

Preparing Stock Solutions for AR-C 141990 hydrochloride

The following data is based on the product molecular weight 529.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.89 mL	9.45 mL	18.90 mL
5 mM	0.38 mL	1.89 mL	3.78 mL
10 mM	0.19 mL	0.95 mL	1.89 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for AR-C 141990 hydrochloride

References are publications that support the biological activity of the product.

Thiesen In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1. J.Pharmacol.Exp.Ther. 2015 PMID: 25986445
Påhlman Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1. Transpl.Int. 2012 PMID: 23137339