ARN 14494

Name: ARN 14494
Brand: Tocris Bioscience
SKU: 7134

Tocris Bioscience, part of Bio-Techne | Catalog # 7134

COA / SDS

Potent serine palmitoyltransferase inhibitor

Key Product Details

Description:	Potent serine palmitoyltransferase inhibitor
Chemical Name:	rel-1-[1-[2-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	424.55

View Full Technical Details for ARN 14494

Technical Data
Citations

Biological Activity for ARN 14494

ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC₅₀ = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

Technical Data for ARN 14494

M. Wt	424.55
Formula	C₂₄H₃₂N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1037834-43-7
PubChem ID	24857490
InChi Key	TYZOOEYUTZDYPB-HDICACEKSA-N
Smiles	[H][C@@]12CCC[C@@]1(CN(C(CN3CCC(N4C(CC5=CC(C(NC)=O)=CC=C45)=O)CC3)=O)C2)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ARN 14494

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	2.12	5
	ethanol	21.23	50

Preparing Stock Solutions for ARN 14494

The following data is based on the product molecular weight 424.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.71 mL	23.55 mL	47.11 mL
2.5 mM	0.94 mL	4.71 mL	9.42 mL
5 mM	0.47 mL	2.36 mL	4.71 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

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References for ARN 14494

References are publications that support the biological activity of the product.

De Vita Inhibition of serine palmitoyltransferase by a small organic molecule promotes neuronal survival after astrocyte amyloid beta 1-42 injury. ACS Chem.Neurosci. 2019 PMID: 30481470