Artesunate

Name: Artesunate
Brand: Tocris Bioscience
SKU: 6827

Tocris Bioscience, part of Bio-Techne | Catalog # 6827

Citations (7)

COA / SDS

Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial

Key Product Details

Description:	Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
Chemical Name:	4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	384.42

View Full Technical Details for Artesunate

Technical Data
Citations

Biological Activity for Artesunate

Artesunate suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G₂/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Aretesumate is an antimalarial (Plasmodium).

Technical Data for Artesunate

M. Wt	384.42
Formula	C₁₉H₂₈O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	88495-63-0
PubChem ID	6917864
InChi Key	FIHJKUPKCHIPAT-AHIGJZGOSA-N
Smiles	[H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@H]([C@@H]2C)OC(CCC(O)=O)=O)(O4)[H])C)[H])C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Artesunate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.44	100
	ethanol	38.44	100

Preparing Stock Solutions for Artesunate

The following data is based on the product molecular weight 384.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.01 mL	26.01 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for Artesunate

References are publications that support the biological activity of the product.

Jeong Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. Oncotarget. 2015 PMID: 26426994
Liu Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome. Inflammation 2018 PMID: 29730819
Meshnick Artemisinin: mechanisms of action, resistance and toxicity. In.J.Parasitol. 2002 PMID: 12435450