AUTAC4

Name: AUTAC4
Brand: Tocris Bioscience
SKU: 7699

Tocris Bioscience, part of Bio-Techne | Catalog # 7699

COA / SDS

Mitochondrial targeting AUTAC Degrader

Key Product Details

Description:	Mitochondrial targeting AUTAC Degrader
Chemical Name:	N-[(16R)-16-[[[2-Amino-9-[(4-fluorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]thio]methyl]-15,18-dioxo-4,7,10-trioxa-14,17-diazanonadec-1-yl]-α-oxo-2-phenyl-1H-indole-3-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	869.97

View Full Technical Details for AUTAC4

Technical Data
Citations

Biological Activity for AUTAC4

AUTAC4 is an autophagy-targeting chimera targeting mitochondria. Comprises p-fluorobenzyl guanine joined by a PEG linker to a 2-phenylindole-3-glyoxyaminde ligand for the translocator protein on the outer mitochondrial membrane. It delivers a guanine tag to the mitochondrial membrane and promotes mitophagy of damaged mitochondria. In Down syndrome cells, AUTAC4 degrades impaired mitochondria and promotes the generation of functionally normal mitochondria.

Licensing Information

Sold under license from Tohoku Techno Arch.

Technical Data for AUTAC4

M. Wt	869.97
Formula	C₄₃H₄₈FN₉O₈S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2267315-04-6
PubChem ID	137409907
InChi Key	IYRHHSZRPVKBSQ-XIFFEERXSA-N
Smiles	CC(N[C@H](C(NCCCOCCOCCOCCCNC(C(C1=C(C2=CC=CC=C2)NC3=CC=CC=C13)=O)=O)=O)CSC4=NC5=C(N4CC6=CC=C(C=C6)F)N=C(NC5=O)N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AUTAC4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.4	20

Preparing Stock Solutions for AUTAC4

The following data is based on the product molecular weight 869.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	5.75 mL	28.74 mL	57.47 mL
1 mM	1.15 mL	5.75 mL	11.49 mL
2 mM	0.57 mL	2.87 mL	5.75 mL
10 mM	0.11 mL	0.57 mL	1.15 mL

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References for AUTAC4

References are publications that support the biological activity of the product.

Takahashi AUTACs: cargo-specific degraders using selective autophagy. Mol.Cell. 2019 PMID: 31606272