AZ 14145845

Name: AZ 14145845
Brand: Tocris Bioscience
SKU: 8023

Tocris Bioscience, part of Bio-Techne | Catalog # 8023

COA / SDS

Dual Mer/Axl inhibitor

Key Product Details

Description:	Dual Mer/Axl inhibitor
Chemical Name:	3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine
Purity:	≥97% (HPLC)
Molecular Weight:	561.69

View Full Technical Details for AZ 14145845

Technical Data
Citations

Biological Activity for AZ 14145845

AZ 14145845 is a potent, and highly selective dual Mer/Axl kinase inhibitor (pIC₅₀= 7 nM and 7.8 nM in pAxl and pMer, respectively). In vivo, AZ 14145845 shows dose-dependent reduction of tumor growth in the Mer and Axl kinase Ba/F3 tumor xenograft model. AZ 14145845 combined with anti-PD1 antibodies and ionizing radiation increases survival in mice with tumors derived from MC38 cells in vivo. AZ 14145845 is orally bioavailable.

Technical Data for AZ 14145845

M. Wt	561.69
Formula	C₃₂H₃₅N₉O
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2830555-70-7
PubChem ID	156596359
InChi Key	CZIXXCVLEHVEBZ-UHFFFAOYSA-N
Smiles	CC1=C(N=CC(C2=C(C)N(C)N=C2C)=C1)C3=NN=C(N(CC4=CN5C(C6=CC=C(CN(C)C)C=C6)=CN=C5C=C4)C)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 14145845

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	56.17	100
	ethanol	56.17	100

Preparing Stock Solutions for AZ 14145845

The following data is based on the product molecular weight 561.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.78 mL	8.90 mL	17.80 mL
5 mM	0.36 mL	1.78 mL	3.56 mL
10 mM	0.18 mL	0.89 mL	1.78 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AZ 14145845

References are publications that support the biological activity of the product.

McCoull Optimization of an Imidazo[1,2.a]pyridine series to afford highly selective type I1/2 Dual Mer/Axl kinase inhibitors with in vivo efficacy. J.Med.Chem. 2021 PMID: 34478292