AZ 191

Name: AZ 191
Brand: Tocris Bioscience
SKU: 5232

Tocris Bioscience, part of Bio-Techne | Catalog # 5232

Citations (3)

COA / SDS

Potent DYRK1B inhibitor

Key Product Details

Description:	Potent DYRK1B inhibitor
Chemical Name:	N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	429.52

View Full Technical Details for AZ 191

Technical Data
Citations

Biological Activity for AZ 191

AZ 191 is a potent DYRK1B inhibitor (IC₅₀ values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced G_i phase cell cycle arrest in Panc-1 cells in vitro.

Compound Libraries for AZ 191

AZ 191 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ 191 is reviewed on the chemical probes website.

Technical Data for AZ 191

M. Wt	429.52
Formula	C₂₄H₂₇N₇O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1594092-37-1
PubChem ID	72716071
InChi Key	ZYVXTMKTGDARKR-UHFFFAOYSA-N
Smiles	CN2C=C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)C1=CC=NC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 191

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.95	100
	ethanol	8.59	20

Preparing Stock Solutions for AZ 191

The following data is based on the product molecular weight 429.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for AZ 191

References are publications that support the biological activity of the product.

Ashford A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3 beta to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem.J. 2014 PMID: 24134204