Banoxantrone dihydrochloride

Name: Banoxantrone dihydrochloride
Brand: Tocris Bioscience
SKU: 4219

Tocris Bioscience, part of Bio-Techne | Catalog # 4219

COA / SDS

Prodrug topoisomerase II inhibitor

Key Product Details

Description:	Prodrug topoisomerase II inhibitor
Alternative Names:	AQ4N
Chemical Name:	1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	517.4

View Full Technical Details for Banoxantrone dihydrochloride

Technical Data
Citations

Biological Activity for Banoxantrone dihydrochloride

Banoxantrone dihydrochloride is a bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC₅₀ >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

Technical Data for Banoxantrone dihydrochloride

M. Wt	517.4
Formula	C₂₂H₂₈N₄O₆.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	252979-56-9
PubChem ID	72941779
InChi Key	SBWCPHUXRZRTDP-UHFFFAOYSA-N
Smiles	OC1=CC=C(O)C2=C1C(C(C(NCC[N+]([O-])(C)C)=CC=C3NCC[N+]([O-])(C)C)=C3C2=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Banoxantrone dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.87	50
	DMSO	12.94	25

Preparing Stock Solutions for Banoxantrone dihydrochloride

The following data is based on the product molecular weight 517.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.87 mL	19.33 mL	38.65 mL
2.5 mM	0.77 mL	3.87 mL	7.73 mL
5 mM	0.39 mL	1.93 mL	3.87 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

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References for Banoxantrone dihydrochloride

References are publications that support the biological activity of the product.

Patterson and McKeown AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br.J.Cancer 2000 PMID: 11104551
Mehibel Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N). Mol.Cancer Ther. 2009 PMID: 19435866
Friery Enhancement of the anti-tumour effect of cyclophosph. by the bioreductive drugs AQ4N and tirapazamine. Br.J.Cancer 2000 PMID: 10780528