BAY 826

Name: BAY 826
Brand: Tocris Bioscience
SKU: 6579

Tocris Bioscience, part of Bio-Techne | Catalog # 6579

Citations (3)

COA / SDS

Potent Tie2 inhibitor

Key Product Details

Description:	Potent Tie2 inhibitor
Chemical Name:	[3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Purity:	≥98% (HPLC)
Molecular Weight:	558.53

View Full Technical Details for BAY 826

Technical Data
Citations

Biological Activity for BAY 826

BAY 826 is a potent Tie 2 inhibitor (IC₅₀ = 1.3 nM for autophosphorylation of Tie2 in HUVECs), which is selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. BAY 826 displays in vivo efficacy in some murine glioma models.

Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.

Compound Libraries for BAY 826

BAY 826 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 826 is reviewed on the chemical probes website.

Technical Data for BAY 826

M. Wt	558.53
Formula	C₂₆H₁₉F₅N₆OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1448316-08-2
PubChem ID	71623052
InChi Key	MPASHPJAIUOWCK-UHFFFAOYSA-N
Smiles	CC1=CC(C)=C(C=C1N2C=CN3N=C(C4=CN=CC=C4)C=C23)NC(C5=CC(S(F)(F)(F)(F)F)=CC(C#N)=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 826

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	100

Preparing Stock Solutions for BAY 826

The following data is based on the product molecular weight 558.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.79 mL	8.95 mL	17.90 mL
5 mM	0.36 mL	1.79 mL	3.58 mL
10 mM	0.18 mL	0.90 mL	1.79 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for BAY 826

References are publications that support the biological activity of the product.

Schneider Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J.Neurochem. 2017 PMID: 27787897