BD 1063 dihydrochloride

Name: BD 1063 dihydrochloride
Brand: Tocris Bioscience
SKU: 0883

Tocris Bioscience, part of Bio-Techne | Catalog # 0883

(2)

Citations (13)

COA / SDS

Selective σ1 ligand, putative antagonist

Key Product Details

Chemical Name:	1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
Purity:	≥99%
Molecular Weight:	346.13 kDa

View Full Technical Details for BD 1063 dihydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for BD 1063 dihydrochloride

BD 1063 dihydrochloride is a σ₁ receptor antagonist, approximately 50-fold selective over σ₂ sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α₁, α₂, β adrenoceptor, 5-HT₁ and 5-HT₂ receptors. Prevents hyperlocomotion following cocaine administration in mice.

Technical Data for BD 1063 dihydrochloride

M. Wt	346.13 kDa
Formula	C₁₃H₁₈Cl₂N₂.2HCl
Storage	Store at RT
Purity	≥99%
CAS Number	206996-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BD 1063 dihydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for BD 1063 dihydrochloride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Zhao J, Ha Y, Liou G, Gonsalvez G, Smith S, Bollinger K Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia. Invest Ophthalmol Vis Sci, 2014;55(6):3375-84. 2014 PMID: 24812552
McCracken et al. Novel σ receptor ligands attenuate the locomotor stimulatory effects of cocaine. Eur.J.Pharmacol., 1999;365:35 PMID: 9988120
Liu et al. Cocaine up-regulated fra-2 and σ-1 receptor gene and protein expression in brain regions involved in addiction and reward. J.Pharmacol.Exp.Ther., 2005;314:770 PMID: 15879001
Matsumoto et al. Characterisation of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism. Eur.J.Pharmacol., 1995;280:301 PMID: 8566098