BI 01383298

Name: BI 01383298
Brand: Tocris Bioscience
SKU: 6518

Tocris Bioscience, part of Bio-Techne | Catalog # 6518

Citations (1)

COA / SDS

Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor

Key Product Details

Description:	Potent and selective SLC13A5 (Na⁺/citrate cotransporter) inhibitor
Chemical Name:	1-[(3,5-Dichlorophenyl)sulfonyl]-N-[(4-fluorophenyl)methyl]-4-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	445.34

View Full Technical Details for BI 01383298

Technical Data
Citations

Biological Activity for BI 01383298

BI 01383298 is a potent and selective inhibitor of human SLC13A5 (Na⁺/citrate cotransporter; IC₅₀ = 56 nM in HEK cells overexpressing hSLC13A5 and 24 nM in HepG2 cells with endogenous SLC13A5 expression). Displays >1000-fold selectivity over other family members.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI01383298 probe summary on the SGC website.

Compound Libraries for BI 01383298

BI 01383298 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BI 01383298

M. Wt	445.34
Formula	C₁₉H₁₉Cl₂FN₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2227549-00-8
PubChem ID	134604213
InChi Key	VUOYAALVGSMUHC-UHFFFAOYSA-N
Smiles	FC1=CC=C(C=C1)CNC(C2CCN(S(=O)(C3=CC(Cl)=CC(Cl)=C3)=O)CC2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BI 01383298

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.27	50

Preparing Stock Solutions for BI 01383298

The following data is based on the product molecular weight 445.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.49 mL	22.45 mL	44.91 mL
2.5 mM	0.90 mL	4.49 mL	8.98 mL
5 mM	0.45 mL	2.25 mL	4.49 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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References for BI 01383298

References are publications that support the biological activity of the product.

Peters Flipping a citrate switch on liver cancer cells. J.Biol.Chem. 2017 PMID: 28821606