BigLEN (mouse)

Name: BigLEN (mouse)
Brand: Tocris Bioscience
SKU: 6304
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6304

(1)

Citations (1)

COA / SDS

GPR171 agonist

Key Product Details

Description:	GPR171 agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1756.03

View Full Technical Details for BigLEN (mouse)

Technical Data
Citations / Reviews (1)

Biological Activity for BigLEN (mouse)

BigLEN (mouse) is a GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

Technical Data for BigLEN (mouse)

M. Wt	1756.03
Formula	C₇₈H₁₃₀N₂₄O₂₂
Single Letter Sequence	LENPSPQAPARRLLPP
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	501036-69-7
PubChem ID	131648250
InChi Key	UEWHHQZTIIRRRA-REWHPCPNSA-N
Smiles	[H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BigLEN (mouse)

Solubility

Soluble to 2mg/ml in water

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References for BigLEN (mouse)

References are publications that support the biological activity of the product.

Mack Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem.Neurosci. 2019 PMID: 30726666
Wardman ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS One 2011 PMID: 22164236