Bisindolylmaleimide II

Name: Bisindolylmaleimide II
Brand: Tocris Bioscience
SKU: 4128
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4128

(1)

Citations (10)

COA / SDS

Potent PKC inhibitor; also potent nAChR antagonist

Key Product Details

Description:	Potent PKC inhibitor; also potent nAChR antagonist
Chemical Name:	3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Purity:	≥97% (HPLC)
Molecular Weight:	438.52

View Full Technical Details for Bisindolylmaleimide II

Technical Data
Citations / Reviews (1)

Biological Activity for Bisindolylmaleimide II

Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor (IC₅₀ = 0.01 μM). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC₅₀ values are 0.75 and 2μM for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC₅₀ ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).

Compound Libraries for Bisindolylmaleimide II

Bisindolylmaleimide II is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Bisindolylmaleimide II

M. Wt	438.52
Formula	C₂₇H₂₆N₄O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	137592-45-1
PubChem ID	2397
InChi Key	LBFDERUQORUFIN-UHFFFAOYSA-N
Smiles	O=C(NC3=O)C(C4=CNC5=C4C=CC=C5)=C3C1=CN(CCC6CCCN6C)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bisindolylmaleimide II

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.85	100

Preparing Stock Solutions for Bisindolylmaleimide II

The following data is based on the product molecular weight 438.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.80 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for Bisindolylmaleimide II

References are publications that support the biological activity of the product.

Mahata Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells. Mol.Pharmacol. 2002 PMID: 12021395
Toullec The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J.Biol.Chem. 1991 PMID: 1874734