BL 1249

Name: BL 1249
Brand: Tocris Bioscience
SKU: 3797
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3797

(1)

Citations (6)

COA / SDS

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

Key Product Details

Description:	K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) activator
Chemical Name:	5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine
Purity:	≥99% (HPLC)
Molecular Weight:	291.35

View Full Technical Details for BL 1249

Technical Data
Citations / Reviews (1)

Biological Activity for BL 1249

BL 1249 is a K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) channel opener (EC₅₀ values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC₅₀ values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).

Technical Data for BL 1249

M. Wt	291.35
Formula	C₁₇H₁₇N₅
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	18200-13-0
PubChem ID	16078951
InChi Key	YYNRZIFBTOUICE-UHFFFAOYSA-N
Smiles	C1(NC3=CC=CC4=C3CCCC4)=CC=CC=C1C2=NN=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BL 1249

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	29.14	100
	DMSO	29.14	100

Preparing Stock Solutions for BL 1249

The following data is based on the product molecular weight 291.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.16 mL	34.32 mL
5 mM	0.69 mL	3.43 mL	6.86 mL
10 mM	0.34 mL	1.72 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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References for BL 1249

References are publications that support the biological activity of the product.

Gonczi Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br.J.Pharmacol. 2006 PMID: 16432512
Pope Protein and chemical determinants of BL-1249 action and selectivity for K_2P channels. ACS Chem.Neurosci. 2018 PMID: 30089357
Tertyshnikova BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J.Pharmacol.Exp.Ther. 2005 PMID: 15608074