BMS 466442

Name: BMS 466442
Brand: Tocris Bioscience
SKU: 6878

Tocris Bioscience, part of Bio-Techne | Catalog # 6878

Citations (1)

COA / SDS

Potent and selective inhibitor of asc-1

Key Product Details

Description:	Potent and selective inhibitor of asc-1
Chemical Name:	N-[[5-Methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-L-histidine methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	538.6

View Full Technical Details for BMS 466442

Technical Data
Citations

Biological Activity for BMS 466442

BMS 466442 is a potent and selective asc-1 (alanine-serine-cysteine-1) transporter inhibitor (IC₅₀ values are 20 and 37 nM in rat primary cortical cultures and HEK cells expressing asc-1 respectively). Displays >1000-fold selectivity for asc-1 over LAT-2 and ASCT-2. This compound is unsuitable for in vivo studies.

Technical Data for BMS 466442

M. Wt	538.6
Formula	C₃₁H₃₀N₄O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1598424-76-0
PubChem ID	124082063
InChi Key	UUCAHZCMRZOTNF-MHZLTWQESA-N
Smiles	COC(=O)[C@H](CC1=CN(CC2=CC=CC=C2)C=N1)NC(=O)C1=CC2=CC(OC)=C(OCC3=CC=CC=C3)C=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 466442

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.86	100

Preparing Stock Solutions for BMS 466442

The following data is based on the product molecular weight 538.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.28 mL	18.57 mL
5 mM	0.37 mL	1.86 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for BMS 466442

References are publications that support the biological activity of the product.

Brown In vitro characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J.Neurochem. 2014 PMID: 24266811
Torrecillas Inhibition of the alanine-serine-cysteine-1 transporter by BMS-466442. ACS Chem.Neurosci. 2019 PMID: 30821959