BMX-IN-1

Name: BMX-IN-1
Brand: Tocris Bioscience
SKU: 5123

Tocris Bioscience, part of Bio-Techne | Catalog # 5123

Citations (1)

COA / SDS

Potent and irreversible BMX inhibitor

Key Product Details

Chemical Name:	N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for BMX-IN-1

BMX-IN-1 is a potent and irreversible BMX inhibitor (IC₅₀ = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.

Technical Data for BMX-IN-1

Formula	C₂₉H₂₄N₄O₄S
Storage	Store at -20°C
Purity	≥98%
CAS Number	1431525-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMX-IN-1

Solubility

Soluble Soluble to 1 mM in DMSO with gentle warming

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References for BMX-IN-1

References are publications that support the biological activity of the product.

Liu et al. Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem.Biol., 2013;8:1423 PMID: 23594111
Li et al. BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget., 2017;8:49238 PMID: 28514765

BMX-IN-1

Tocris Bioscience, part of Bio-Techne | Catalog # 5123

Key Product Details

Biological Activity for BMX-IN-1

Technical Data for BMX-IN-1

Solubility for BMX-IN-1

Dilution Calculator

Reconstitution Calculator

References for BMX-IN-1

Product Documents for BMX-IN-1

COA

Certificate of Analysis

SDS

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