BRL 37344, sodium salt

Name: BRL 37344, sodium salt
Brand: Tocris Bioscience
SKU: 0948

Tocris Bioscience, part of Bio-Techne | Catalog # 0948

Citations (4)

COA / SDS

β3 agonist

Key Product Details

Description:	β₃ agonist
Chemical Name:	(R,R)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	385.82

View Full Technical Details for BRL 37344, sodium salt

Technical Data
Citations

Biological Activity for BRL 37344, sodium salt

BRL 37344, sodium salt is a potent and selective β₃ adrenoceptor agonist (K_i values are 287, 1750 and 1120 nM for β₃, β₁ and β₂ receptors respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for BRL 37344, sodium salt

M. Wt	385.82
Formula	C₁₉H₂₁NO₄ClNa
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	127299-93-8
PubChem ID	16219010
InChi Key	SNJIJYKMYQRHRC-WJKBNZMCSA-M
Smiles	[Na+].C[C@H](CC1=CC=C(OCC([O-])=O)C=C1)NC[C@H](O)C1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BRL 37344, sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	38.58	100

Preparing Stock Solutions for BRL 37344, sodium salt

The following data is based on the product molecular weight 385.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.96 mL	25.92 mL
5 mM	0.52 mL	2.59 mL	5.18 mL
10 mM	0.26 mL	1.30 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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Reconstitution Calculator

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References for BRL 37344, sodium salt

References are publications that support the biological activity of the product.

Strosberg and Pietri-Rouxel Function and regulation of the β₃-adrenoceptor. TiPS 1996 PMID: 8979772
Ayo Oriowo The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 1996 PMID: 8613923
Board BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 2000 PMID: 11011029
Arch Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 1984 PMID: 6325935