BVT 948

Name: BVT 948
Brand: Tocris Bioscience
SKU: 2176

Tocris Bioscience, part of Bio-Techne | Catalog # 2176

Citations (6)

COA / SDS

Non-competitive protein tyrosine phosphatase inhibitor

Key Product Details

Description:	Non-competitive protein tyrosine phosphatase inhibitor
Chemical Name:	4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	241.25

View Full Technical Details for BVT 948

Technical Data
Citations

Biological Activity for BVT 948

BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC₅₀ = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC₅₀ <10 μM).

Compound Libraries for BVT 948

BVT 948 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for BVT 948

M. Wt	241.25
Formula	C₁₄H₁₁NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	39674-97-0
PubChem ID	6604934
InChi Key	LLPBUXODFQZPFH-UHFFFAOYSA-N
Smiles	CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BVT 948

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	12.06	50
	DMSO	12.06	50

Preparing Stock Solutions for BVT 948

The following data is based on the product molecular weight 241.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.29 mL	41.45 mL	82.90 mL
2.5 mM	1.66 mL	8.29 mL	16.58 mL
5 mM	0.83 mL	4.15 mL	8.29 mL
25 mM	0.17 mL	0.83 mL	1.66 mL

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References for BVT 948

References are publications that support the biological activity of the product.

Liljebris Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 2004 PMID: 14747616