Candesartan

Name: Candesartan
Brand: Tocris Bioscience
SKU: 4791

Tocris Bioscience, part of Bio-Techne | Catalog # 4791

Citations (27)

COA / SDS

AT1 antagonist

Key Product Details

Description:	AT₁ antagonist
Alternative Names:	CV 11974
Chemical Name:	2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	440.45

View Full Technical Details for Candesartan

Technical Data
Citations

Biological Activity for Candesartan

Candesartan is an angiotensin II receptor 1 (AT₁) antagonist (IC₅₀ values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).

Compound Libraries for Candesartan

Candesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Candesartan

M. Wt	440.45
Formula	C₂₄H₂₀N₆O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	139481-59-7
PubChem ID	2541
InChi Key	HTQMVQVXFRQIKW-UHFFFAOYSA-N
Smiles	CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Candesartan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.45	100
	ethanol	0.44	10 with gentle warming

Preparing Stock Solutions for Candesartan

The following data is based on the product molecular weight 440.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.35 mL	22.70 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.14 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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Reconstitution Calculator

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References for Candesartan

References are publications that support the biological activity of the product.

Shibouta Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 1993 PMID: 8331552