CASIN

Name: CASIN
Brand: Tocris Bioscience
SKU: 5050

Tocris Bioscience, part of Bio-Techne | Catalog # 5050

Citations (13)

COA / SDS

Cdc42 inhibitor

Key Product Details

Chemical Name:	2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
Purity:	≥98%

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Technical Data
Citations

Biological Activity for CASIN

CASIN is a Cdc42 GTPase inhibitor (IC₅₀ = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.

Technical Data for CASIN

Formula	C₂₀H₂₂N₂O
Storage	Store at -20°C
Purity	≥98%
CAS Number	425399-05-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CASIN

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for CASIN

References are publications that support the biological activity of the product.

F Weeber, A Becher, T Seibold, T Seufferlei, T Eiseler Concerted regulation of actin polymerization during constitutive secretion by Cortactin and PKD2 J. Cell. Sci., 2019;0(0):. 2019 PMID: 31727638
Li et al. Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell, 2013;13:270 PMID: 24012368
Florian et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell, 2012;10:520 PMID: 22560076
Peterson et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem.Biol., 2006;13:443 PMID: 16632257

CASIN

Tocris Bioscience, part of Bio-Techne | Catalog # 5050

Key Product Details

Biological Activity for CASIN

Technical Data for CASIN

Solubility for CASIN

Dilution Calculator

Reconstitution Calculator

References for CASIN

Product Documents for CASIN

COA

Certificate of Analysis

SDS

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