CASIN

Name: CASIN
Brand: Tocris Bioscience
SKU: 5050

Tocris Bioscience, part of Bio-Techne | Catalog # 5050

Citations (13)

COA / SDS

Cdc42 inhibitor

Key Product Details

Description:	Cdc42 inhibitor
Chemical Name:	2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
Purity:	≥98% (HPLC)
Molecular Weight:	306.4

View Full Technical Details for CASIN

Technical Data
Citations

Biological Activity for CASIN

CASIN is a Cdc42 GTPase inhibitor (IC₅₀ = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.

Compound Libraries for CASIN

CASIN is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CASIN

M. Wt	306.4
Formula	C₂₀H₂₂N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	425399-05-9
PubChem ID	2882155
InChi Key	RXIUMAOXORBRCY-UHFFFAOYSA-N
Smiles	OCCNC1C2=C(C(C=C(C4=CC=CC=C4)C=C3)=C3N2)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CASIN

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.64	100
	ethanol	15.32	50

Preparing Stock Solutions for CASIN

The following data is based on the product molecular weight 306.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.26 mL	16.32 mL	32.64 mL
5 mM	0.65 mL	3.26 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.26 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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Reconstitution Calculator

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References for CASIN

References are publications that support the biological activity of the product.

Peterson Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem.Biol. 2006 PMID: 16632257
Li Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 2013 PMID: 24012368
Florian Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012 PMID: 22560076