CATPB

Tocris Bioscience, part of Bio-Techne | Catalog # 5903

COA / SDS

FFA2 (GPR43) inverse agonist

Key Product Details

Description:	FFA2 (GPR43) inverse agonist
Chemical Name:	(S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	399.79

View Full Technical Details for CATPB

Technical Data
Citations

Biological Activity for CATPB

CATPB is a FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.

Technical Data for CATPB

M. Wt	399.79
Formula	C₁₉H₁₇ClF₃NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1322598-09-3
PubChem ID	53308747
InChi Key	QOSIJVVNNGXEKE-INIZCTEOSA-N
Smiles	OC(C[C@@H](NC(CC1=CC=CC(Cl)=C1)=O)CC2=CC=C(C(F)(F)F)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CATPB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.98	100
	ethanol	19.99	50

Preparing Stock Solutions for CATPB

The following data is based on the product molecular weight 399.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.51 mL	25.01 mL
5 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

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Reconstitution Calculator

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References for CATPB

References are publications that support the biological activity of the product.

Sergeev Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 2016 PMID: 26518871
Park Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 2016 PMID: 26683635