Cevimeline hydrochloride

Name: Cevimeline hydrochloride
Brand: Tocris Bioscience
SKU: 3689

Tocris Bioscience, part of Bio-Techne | Catalog # 3689

Citations (1)

COA / SDS

Selective M1 agonist

Key Product Details

Description:	Selective M₁ agonist
Alternative Names:	AF 102B,SNI 2011
Chemical Name:	cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride
Molecular Weight:	235.77

View Full Technical Details for Cevimeline hydrochloride

Technical Data
Citations

Biological Activity for Cevimeline hydrochloride

Cevimeline hydrochloride is a selective M₁ receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC₅₀ values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

Technical Data for Cevimeline hydrochloride

M. Wt	235.77
Formula	C₁₀H₁₇NOS.HCl
Storage	Store at -20°C
CAS Number	107220-28-0
PubChem ID	76965955
InChi Key	SKFLGMLYGHWKJG-RXUMEZLZSA-N
Smiles	C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cevimeline hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.68	75
	DMSO	11.79	50

Preparing Stock Solutions for Cevimeline hydrochloride

The following data is based on the product molecular weight 235.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.66 mL	28.28 mL	56.55 mL
3.75 mM	1.13 mL	5.66 mL	11.31 mL
7.5 mM	0.57 mL	2.83 mL	5.66 mL
37.5 mM	0.11 mL	0.57 mL	1.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Cevimeline hydrochloride

References are publications that support the biological activity of the product.

Fisher (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M₁ selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 1991 PMID: 2019998
Hargreaves L-689,660, a novel cholinomimetic with functional selectivity for M₁ and M₃ muscarinic receptors. Br.J.Pharmacol. 1992 PMID: 1422595
Wanibuchi Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 1990 PMID: 1963596