CGP 12177 hydrochloride

Name: CGP 12177 hydrochloride
Brand: Tocris Bioscience
SKU: 1134

Tocris Bioscience, part of Bio-Techne | Catalog # 1134

Citations (8)

COA / SDS

β3 partial agonist. β1/β2 antagonist

Key Product Details

Description:	β₃ partial agonist. β₁/β₂ antagonist
Chemical Name:	4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride
Molecular Weight:	315.8

View Full Technical Details for CGP 12177 hydrochloride

Technical Data
Citations

Biological Activity for CGP 12177 hydrochloride

CGP 12177 hydrochloride is a partial agonist at β₃-adrenoceptors. β₁- and β₂-adrenoceptor antagonist (K_i values are 0.9, 4 and 88 nM for β₁, β₂ and β₃ receptors respectively).

Technical Data for CGP 12177 hydrochloride

M. Wt	315.8
Formula	C₁₄H₂₁N₃O₃.HCl
Storage	Store at RT
CAS Number	64208-32-8
PubChem ID	11957517
InChi Key	YQVFCYCTITZLSX-UHFFFAOYSA-N
Smiles	Cl.CC(C)(C)NCC(O)COC1=CC=CC2=C1NC(=O)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 12177 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		50

Preparing Stock Solutions for CGP 12177 hydrochloride

The following data is based on the product molecular weight 315.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.33 mL	31.67 mL	63.33 mL
2.5 mM	1.27 mL	6.33 mL	12.67 mL
5 mM	0.63 mL	3.17 mL	6.33 mL
25 mM	0.13 mL	0.63 mL	1.27 mL

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References for CGP 12177 hydrochloride

References are publications that support the biological activity of the product.

Strosberg and Pietri-Rouxel Function and regulation of the β₃-adrenoceptor. TiPS 1996 PMID: 8979772
Preitner Metabolic response to various β-adrenoceptor agonists in β₃-adrenoceptor knockout mice: evidence for a new β-adrenergic receptor in brown adipose tissue. Br.J.Pharmacol. 1998 PMID: 9756384
Staehelin CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells. J.Biol.Chem. 1983 PMID: 6131886
Galitzky On the presence of a putative fourth β-adrenoceptor in human adipose tissue. TiPS 1998 PMID: 9652187