CGRP 8-37 (rat)

Name: CGRP 8-37 (rat)
Brand: Tocris Bioscience
SKU: 1169

Tocris Bioscience, part of Bio-Techne | Catalog # 1169

Citations (11)

COA / SDS

CGRP antagonist

Key Product Details

Description:	CGRP antagonist
Alternative Names:	Calcitonin Gene-Related Peptide 8-37 (rat)
Purity:	≥95% (HPLC)
Molecular Weight:	3127.5

View Full Technical Details for CGRP 8-37 (rat)

Technical Data
Citations

Biological Activity for CGRP 8-37 (rat)

CGRP 8-37 (rat) is a peptide antagonist for CGRP₁ receptors.

Technical Data for CGRP 8-37 (rat)

M. Wt	3127.5
Formula	C₁₃₈H₂₂₄N₄₂O₄₁
Single Letter Sequence	VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF (Modification: Phe-30 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	129121-73-9
PubChem ID	90479762
InChi Key	HZKKKBMPFPSSKZ-QZMRZBIOSA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGRP 8-37 (rat)

Solubility

Soluble to 1mg/ml in water

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References for CGRP 8-37 (rat)

References are publications that support the biological activity of the product.

Poyner Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br.J.Pharmacol. 1998 PMID: 9756381
Wisskirchen Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br.J.Pharmacol. 1998 PMID: 9605575
Poyner Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 1995 PMID: 8578616