CGS 9343B

Name: CGS 9343B
Brand: Tocris Bioscience
SKU: 2255

Tocris Bioscience, part of Bio-Techne | Catalog # 2255

Citations (11)

COA / SDS

Calmodulin antagonist

Key Product Details

Description:	Calmodulin antagonist
Alternative Names:	Zaldaride maleate
Chemical Name:	1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Purity:	≥98% (HPLC)
Molecular Weight:	544.61

View Full Technical Details for CGS 9343B

Technical Data
Citations

Biological Activity for CGS 9343B

CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC₅₀ of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

Technical Data for CGS 9343B

M. Wt	544.61
Formula	C₂₆H₂₈N₄O₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	109826-27-9
PubChem ID	6450522
InChi Key	NGODOSILXOFQPH-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGS 9343B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.23	50
	ethanol	5.45	10 with gentle warming

Preparing Stock Solutions for CGS 9343B

The following data is based on the product molecular weight 544.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.67 mL	18.36 mL	36.72 mL
2.5 mM	0.73 mL	3.67 mL	7.34 mL
5 mM	0.37 mL	1.84 mL	3.67 mL
25 mM	0.07 mL	0.37 mL	0.73 mL

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References for CGS 9343B

References are publications that support the biological activity of the product.

Neuhaus and Reber Inhibition of membrane currents and rises of intracellular Ca²⁺ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 1992 PMID: 1379190
Li Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 2003 PMID: 12419798
Norman CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 1987 PMID: 3033469