CGS 9343B

Name: CGS 9343B
Brand: Tocris Bioscience
SKU: 2255

Tocris Bioscience, part of Bio-Techne | Catalog # 2255

Citations (11)

COA / SDS

Calmodulin antagonist

Key Product Details

Chemical Name:	1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Purity:	≥98%
Molecular Weight:	544.61 kDa

View Full Technical Details for CGS 9343B

Technical Data
Citations

Biological Activity for CGS 9343B

CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC₅₀ of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

Technical Data for CGS 9343B

M. Wt	544.61 kDa
Formula	C₂₆H₂₈N₄O₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98%
CAS Number	109826-27-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGS 9343B

Solubility

Soluble Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CGS 9343B

References are publications that support the biological activity of the product.

Norman et al. CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol., 1987;31:535 PMID: 3033469
Neuhaus and Reber Inhibition of membrane currents and rises of intracellular Ca²⁺ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol., 1992;226:183 PMID: 1379190
Li et al. Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem., 2003;278:1195 PMID: 12419798