Chelerythrine chloride

Name: Chelerythrine chloride
Brand: Tocris Bioscience
SKU: 1330

Tocris Bioscience, part of Bio-Techne | Catalog # 1330

Citations (49)

COA / SDS

Cell-permeable protein kinase C inhibitor

Key Product Details

Chemical Name:	1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Purity:	≥98%
Molecular Weight:	383.83 kDa

View Full Technical Details for Chelerythrine chloride

Technical Data
Citations

Biological Activity for Chelerythrine chloride

Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC₅₀ = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of Bcl_XL to Bak (IC₅₀ = 1.5 μM) or Bad proteins and stimulates apoptosis.

Technical Data for Chelerythrine chloride

M. Wt	383.83 kDa
Formula	C₂₁H₁₈ClNO₄
Storage	Desiccate at -20°C
Purity	≥98%
CAS Number	3895-92-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chelerythrine chloride

Solubility

Soluble Soluble to 10 mM in water and to 10 mM in DMSO

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References for Chelerythrine chloride

References are publications that support the biological activity of the product.

Morelli, Maria Be, Amantini, Consuelo, Nabissi, Massimo, Liberati, Sonia, Cardinali, Claudio, Farfariello, Valerio, Tomassoni, Daniele, Quaglia, Wilma, Piergentili, Alessand, Bonifazi, Alessand, Del Bello, Fabio, Santoni, Matteo, Mammana, Gabriele, Servi, Lucilla, Filosa, Alessand, Gismondi, Angela, Santoni, Giorgio Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. BMC Cancer, 2014;14(0):921. 2014 PMID: 25481381
Chan et al. Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem., 2003;278:20453 PMID: 12702731
Lee et al. Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem., 1998;273:19829 PMID: 9677417
Herbert et al. Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Commun., 1990;172:993 PMID: 2244923
Yu et al. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem., 2000;275:9612 PMID: 10734112