CHR 2797

Name: CHR 2797
Brand: Tocris Bioscience
SKU: 3595

Tocris Bioscience, part of Bio-Techne | Catalog # 3595

Citations (6)

COA / SDS

Aminopeptidase inhibitor

Key Product Details

Description:	Aminopeptidase inhibitor
Alternative Names:	Tosedostat
Chemical Name:	α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneacetic acid cyclopently ester
Purity:	≥98% (HPLC)
Molecular Weight:	406.48

View Full Technical Details for CHR 2797

Technical Data
Citations

Biological Activity for CHR 2797

CHR 2797 is an aminopeptidase inhibitor (IC₅₀ values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA₄ hydrolase and MetAP2, respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo. Also inhibits neprilysin (IC₅₀ = 900 nM). Exhibits antinociceptive activity and enhances the efficacy of Morphine (Cat. No. 5158) in the hot-plate and tail-flick assays, via an action on the peripheral nervous system.

Compound Libraries for CHR 2797

CHR 2797 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CHR 2797

M. Wt	406.48
Formula	C₂₁H₃₀N₂O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	238750-77-1
PubChem ID	15547703
InChi Key	FWFGIHPGRQZWIW-SQNIBIBYSA-N
Smiles	O=C([C@H]([C@]2=CC=CC=C2)NC([C@@H]([C@@H](C(NO)=O)O)CC(C)C)=O)OC1CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHR 2797

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.65	100
	ethanol	20.32	50

Preparing Stock Solutions for CHR 2797

The following data is based on the product molecular weight 406.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.30 mL	24.60 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for CHR 2797

References are publications that support the biological activity of the product.

Moore Aminopeptidase inhibition as a targeted treatment strategy in myeloma. Mol.Cancer Ther. 2009 PMID: 19372548
Singh Discovery of anticancer clinical candidate, Tosedostat, as an analgesic agent. ACS Chem.Neurosci. 2019 PMID: 31415151
Krige CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 PMID: 18701491