CI 966 hydrochloride

Name: CI 966 hydrochloride
Brand: Tocris Bioscience
SKU: 1296

Tocris Bioscience, part of Bio-Techne | Catalog # 1296

Citations (2)

COA / SDS

Selective inhibitor of GAT-1

Key Product Details

Description:	Selective inhibitor of GAT-1
Chemical Name:	1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	509.87

View Full Technical Details for CI 966 hydrochloride

Technical Data
Citations

Biological Activity for CI 966 hydrochloride

CI 966 hydrochloride is a selective inhibitor of the GABA transporter GAT-1 (IC₅₀ values are 0.26 and 1.2 μM at cloned human and rat GAT-1 respectively). Displays over 200-fold selectivity over GAT-2 and GAT-3. Centrally active upon systemic administration in vivo. Anticonvulsive and neuroprotective.

Compound Libraries for CI 966 hydrochloride

CI 966 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CI 966 hydrochloride

M. Wt	509.87
Formula	C₂₃H₂₁F₆NO₃.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	110283-66-4
PubChem ID	198692
InChi Key	NUQWSOWKRTZJTO-UHFFFAOYSA-N
Smiles	Cl.OC(=O)C1=CCCN(CCOC(C2=CC=C(C=C2)C(F)(F)F)C2=CC=C(C=C2)C(F)(F)F)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CI 966 hydrochloride

	Solvent	Max Conc. mM
Solubility
	ethanol	10
	DMSO	100

Preparing Stock Solutions for CI 966 hydrochloride

The following data is based on the product molecular weight 509.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.81 mL	19.61 mL
5 mM	0.39 mL	1.96 mL	3.92 mL
10 mM	0.20 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for CI 966 hydrochloride

References are publications that support the biological activity of the product.

Ebert Systemic CI-966, a new gamma-aminobutyric acid uptake blocker, enhances gamma-aminobutyric acid action in CA1 pyramidal layer in situ. Can.J.Physiol.Pharmacol. 1990 PMID: 2276082
Radulovic Pharmacokinetics, mass balance, and induction potential of novel GABA uptake inhibitor, CI-966 HCl, in laboratory animals. Pharm.Res. 1993 PMID: 8272405
Borden Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 1994 PMID: 7851497