CI 976

Name: CI 976
Brand: Tocris Bioscience
SKU: 2227

Tocris Bioscience, part of Bio-Techne | Catalog # 2227

Citations (6)

COA / SDS

Selective ACAT inhibitor

Key Product Details

Description:	Selective ACAT inhibitor
Chemical Name:	2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Purity:	≥98% (HPLC)
Molecular Weight:	393.57

View Full Technical Details for CI 976

Technical Data
Citations

Biological Activity for CI 976

CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC₅₀ = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC₅₀ = 15 μM).

Compound Libraries for CI 976

CI 976 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CI 976

M. Wt	393.57
Formula	C₂₃H₃₉NO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	114289-47-3
PubChem ID	122327
InChi Key	WAFNZAURAWBNDZ-UHFFFAOYSA-N
Smiles	CCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CI 976

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	19.68	50
	DMSO	39.36	100

Preparing Stock Solutions for CI 976

The following data is based on the product molecular weight 393.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.70 mL	25.41 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for CI 976

References are publications that support the biological activity of the product.

Sliskovic and White Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS.
Drecktrah Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol.Biol.Cell
Krause In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J.Lipid Res. 1993 PMID: 8429262