CID 755673

Name: CID 755673
Brand: Tocris Bioscience
SKU: 3327
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3327

(1)

Citations (39)

COA / SDS

Selective protein kinase D inhibitor

Key Product Details

Description:	Selective protein kinase D inhibitor
Chemical Name:	2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	217.22

View Full Technical Details for CID 755673

Technical Data
Citations / Reviews (1)

Biological Activity for CID 755673

CID 755673 is a selective protein kinase D (PKD) inhibitor (IC₅₀ values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.

Compound Libraries for CID 755673

CID 755673 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CID 755673

M. Wt	217.22
Formula	C₁₂H₁₁NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	521937-07-5
PubChem ID	755673
InChi Key	AACFPJSJOWQNBN-UHFFFAOYSA-N
Smiles	OC1=CC2=C(OC3=C2CCCNC3=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CID 755673

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.72	100

Preparing Stock Solutions for CID 755673

The following data is based on the product molecular weight 217.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.60 mL	23.02 mL	46.04 mL
5 mM	0.92 mL	4.60 mL	9.21 mL
10 mM	0.46 mL	2.30 mL	4.60 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

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References for CID 755673

References are publications that support the biological activity of the product.

Sharlow Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone. J.Biol.Chem. 2008 PMID: 18829454