Cilnidipine

Name: Cilnidipine
Brand: Tocris Bioscience
SKU: 2629
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2629

(1)

Citations (3)

COA / SDS

Dual CaV1.x and CaV2.x blocker

Key Product Details

Description:	Dual Ca_V1.x and Ca_V2.x blocker
Alternative Names:	FRC 8653
Chemical Name:	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	492.52

View Full Technical Details for Cilnidipine

Technical Data
Citations / Reviews (1)

Biological Activity for Cilnidipine

Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Compound Libraries for Cilnidipine

Cilnidipine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Cilnidipine

M. Wt	492.52
Formula	C₂₇H₂₈N₂O₇
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	132203-70-4
PubChem ID	2752
InChi Key	KJEBULYHNRNJTE-UHFFFAOYSA-N
Smiles	COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCC=CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cilnidipine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.25	100
	ethanol	4.92	10

Preparing Stock Solutions for Cilnidipine

The following data is based on the product molecular weight 492.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.15 mL	20.30 mL
5 mM	0.41 mL	2.03 mL	4.06 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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Reconstitution Calculator

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References for Cilnidipine

References are publications that support the biological activity of the product.

Takahara Neuroprotective effects of a dual L/N-type Ca²⁺ channel blocker cilnidipine in the rat focal brain ischemia model. Biol.Pharm.Bull. 2004 PMID: 15340224
Nap The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists. Fund.Clin.Pharmacol.
Murai Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 2000 PMID: 10784100