Cilostazol

Name: Cilostazol
Brand: Tocris Bioscience
SKU: 1692

Tocris Bioscience, part of Bio-Techne | Catalog # 1692

Citations (10)

COA / SDS

PDE3A inhibitor. Also adenosine uptake inhibitor

Key Product Details

Description:	PDE3A inhibitor. Also adenosine uptake inhibitor
Chemical Name:	6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
Purity:	≥99% (HPLC)
Molecular Weight:	369.47

View Full Technical Details for Cilostazol

Technical Data
Citations

Biological Activity for Cilostazol

Cilostazol is a potent phosphodiesterase III A (PDE3A) inhibitor (IC₅₀ = 0.2 μM) and inhibitor of adenosine uptake. Has antimitogenic, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.

Compound Libraries for Cilostazol

Cilostazol is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Cilostazol

M. Wt	369.47
Formula	C₂₀H₂₇N₅O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	73963-72-1
PubChem ID	2754
InChi Key	RRGUKTPIGVIEKM-UHFFFAOYSA-N
Smiles	O=C1CCC2=CC(OCCCCC3=NN=NN3C3CCCCC3)=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cilostazol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	3.69	10
	DMSO	18.47	50

Preparing Stock Solutions for Cilostazol

The following data is based on the product molecular weight 369.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.41 mL	27.07 mL	54.13 mL
2.5 mM	1.08 mL	5.41 mL	10.83 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

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Reconstitution Calculator

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References for Cilostazol

References are publications that support the biological activity of the product.

Shintani General pharmacological properties of cilostazol, a new antithrombotic drug. Part I: effects on the central nervous system. Arzneimittelforschung 1985 PMID: 4074429
Shintani General pharmacological properties of cilostazol, a new antithrombotic drug. Part II: effects on the peripheral organs. Arzneimittelforschung 1985 PMID: 3000392
Schror The pharmacology of cilos. Diabetes Obes.Metab. 2002 PMID: 12180353