CL 316243 disodium salt

Name: CL 316243 disodium salt
Brand: Tocris Bioscience
SKU: 1499

Tocris Bioscience, part of Bio-Techne | Catalog # 1499

Citations (53)

COA / SDS

Highly selective β3 agonist

Key Product Details

Description:	Highly selective β₃ agonist
Chemical Name:	5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Purity:	≥97% (HPLC)
Molecular Weight:	465.8

View Full Technical Details for CL 316243 disodium salt

Technical Data
Citations

Biological Activity for CL 316243 disodium salt

CL 316243 disodium salt is a potent and highly selective β₃-adrenoceptor agonist (EC₅₀ = 3 nM); > 10000-fold selective over β₁ and β₂ receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.

Technical Data for CL 316243 disodium salt

M. Wt	465.8
Formula	C₂₀H₁₈ClNNa₂O₇
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	138908-40-4
PubChem ID	5312115
InChi Key	FUZBPOHHSBDTJQ-CFOQQKEYSA-L
Smiles	[Na+].[Na+].C[C@H](CC1=CC=C2OC(OC2=C1)(C([O-])=O)C([O-])=O)NC[C@H](O)C1=CC=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CL 316243 disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	46.58	100

Preparing Stock Solutions for CL 316243 disodium salt

The following data is based on the product molecular weight 465.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.47 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for CL 316243 disodium salt

References are publications that support the biological activity of the product.

Woods Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat. J.Urol. 2001 PMID: 11490313
Yoshida Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β₃-adrenoceptor agonist, in yellow KK mice. Life Sci. 1994 PMID: 8309351
Bloom Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and a J.Med.Chem. 1992 PMID: 1354264