Clocinnamox mesylate

Name: Clocinnamox mesylate
Brand: Tocris Bioscience
SKU: 0898

Tocris Bioscience, part of Bio-Techne | Catalog # 0898

Citations (2)

COA / SDS

Irreversible μ antagonist

Key Product Details

Description:	Irreversible μ antagonist
Alternative Names:	NIH 10443,C-CAM
Chemical Name:	14β-(p-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylmorphinone mesylate
Purity:	≥98% (HPLC)
Molecular Weight:	601.11

View Full Technical Details for Clocinnamox mesylate

Technical Data
Citations

Biological Activity for Clocinnamox mesylate

Clocinnamox mesylate is a systemically active, irreversible μ-opioid receptor antagonist (apparent K_i values are 0.7, 1.9 and 5.7 nM for mouse μ, δ and κ receptors respectively).

Technical Data for Clocinnamox mesylate

M. Wt	601.11
Formula	C₂₉H₂₉ClN₂O₄.CH₃SO₃H
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	117332-69-1
PubChem ID	90479744
InChi Key	XAXNKAGAUFXFDO-JVJDXIHNSA-N
Smiles	C[S](O)(=O)=O.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]5(CCC2=O)NC(=O)C=CC1=CC=C(Cl)C=C1)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Clocinnamox mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	60.11	100
	ethanol	15.03	25

Preparing Stock Solutions for Clocinnamox mesylate

The following data is based on the product molecular weight 601.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.32 mL	16.64 mL
5 mM	0.33 mL	1.66 mL	3.33 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Clocinnamox mesylate

References are publications that support the biological activity of the product.

Broadbear Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, β-funaltrexamine, and β-chlornaltrexamine. J.Pharmacol.Exp.Ther. 2000 PMID: 10945843
Burke Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice. J.Pharmacol.Exp.Ther. 1994 PMID: 7965787
Zernig Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and ex vivo binding and behavioural assays. J.Pharmacol.Exp.Ther. 1996 PMID: 8858971
Aceto Very long-acting narcotic antagonists. The 14β-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives. Arzneimittelforschung 1989 PMID: 2547389