Clofarabine

Name: Clofarabine
Brand: Tocris Bioscience
SKU: 2600

Tocris Bioscience, part of Bio-Techne | Catalog # 2600

Citations (3)

COA / SDS

Deoxycytidine kinase (dCK) substrate

Key Product Details

Chemical Name:	2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Purity:	≥99%

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Technical Data
Citations

Biological Activity for Clofarabine

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC₅₀ = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

Technical Data for Clofarabine

Formula	C₁₀H₁₁ClFN₅O₃
Storage	Store at +4°C
Purity	≥99%
CAS Number	123318-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Clofarabine

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Clofarabine

References are publications that support the biological activity of the product.

Parker et al. Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res., 1991;51:2386 PMID: 1707752
Bonate et al. Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat.Rev.Drug Discov., 2006;5:855 PMID: 17016426
Carson et al. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proc.Natl.Acad.Sci.USA, 1992;89:2970

Clofarabine

Tocris Bioscience, part of Bio-Techne | Catalog # 2600

Key Product Details

Biological Activity for Clofarabine

Technical Data for Clofarabine

Solubility for Clofarabine

Dilution Calculator

Reconstitution Calculator

References for Clofarabine

Product Documents for Clofarabine

COA

Certificate of Analysis

SDS

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