Clonidine hydrochloride

Name: Clonidine hydrochloride
Brand: Tocris Bioscience
SKU: 0690
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0690

(1)

Citations (31)

COA / SDS

α2 agonist. Also I1 ligand

Key Product Details

Description:	α₂ agonist. Also I₁ ligand
Chemical Name:	2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	266.56

View Full Technical Details for Clonidine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Clonidine hydrochloride

Clonidine hydrochloride is a prototypical I₁ imidazoline receptor ligand. α₂-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data for Clonidine hydrochloride

M. Wt	266.56
Formula	C₉H₉Cl₂N₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	4205-91-8
PubChem ID	20179
InChi Key	ZNIFSRGNXRYGHF-UHFFFAOYSA-N
Smiles	Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Clonidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.66	100
	DMSO	13.33	50

Preparing Stock Solutions for Clonidine hydrochloride

The following data is based on the product molecular weight 266.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.76 mL	37.52 mL
5 mM	0.75 mL	3.75 mL	7.50 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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Reconstitution Calculator

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References for Clonidine hydrochloride

References are publications that support the biological activity of the product.

Williams Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 2008 PMID: 18391949
Silva Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 1996 PMID: 8627569
Ernsberger clon. binds to imidazole binding sites as well as α₂-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 1987 PMID: 3030779
Greney Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 1994 PMID: 7883019
Armitsu Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 1998 PMID: 9694921