COG 133

Name: COG 133
Brand: Tocris Bioscience
SKU: 3405

Tocris Bioscience, part of Bio-Techne | Catalog # 3405

Citations (4)

COA / SDS

ApoE peptide fragment

Key Product Details

Description:	ApoE peptide fragment
Alternative Names:	apoE(133-149)
Purity:	≥95% (HPLC)
Molecular Weight:	2169.73

View Full Technical Details for COG 133

Technical Data
Citations

Biological Activity for COG 133

COG 133 is an apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC₅₀ = 445 nM).

Technical Data for COG 133

M. Wt	2169.73
Formula	C₉₇H₁₈₁N₃₇O₁₉
Single Letter Sequence	LRVRLASHLRKLRKRLL (Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	514200-66-9
PubChem ID	16201427
InChi Key	QTWXJKVJIKDSLC-KIZXDXQLSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for COG 133

Solubility

Soluble to 1mg/ml in water

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References for COG 133

References are publications that support the biological activity of the product.

Li Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. J.Pharmacol.Exp.Ther. 2006 PMID: 16740622
Sheng N-MthD.-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology 2008 PMID: 18602124
Gay Apolipoprotein E-derived peptides block α7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 2006 PMID: 16249370