CP 775146

Name: CP 775146
Brand: Tocris Bioscience
SKU: 4190

Tocris Bioscience, part of Bio-Techne | Catalog # 4190

Citations (3)

COA / SDS

Selective, high affinity PPARα agonist

Key Product Details

Description:	Selective, high affinity PPARα agonist
Chemical Name:	2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	423.54

View Full Technical Details for CP 775146

Technical Data
Citations

Biological Activity for CP 775146

CP 775146 is a selective, high affinity PPARα agonist (K_i values are 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Exhibits hypolipidemic activity in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 775146

CP 775146 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 775146

M. Wt	423.54
Formula	C₂₆H₃₃NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	702680-17-9
PubChem ID	10410059
InChi Key	OISHBINQIFNIPV-JOCHJYFZSA-N
Smiles	O=C(CC3=CC=C(C(C)C)C=C3)N(C2)CCC[C@H]2[C@@]1=CC(OC(C)(C)C(O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 775146

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.35	100

Preparing Stock Solutions for CP 775146

The following data is based on the product molecular weight 423.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.36 mL	11.81 mL	23.61 mL
5 mM	0.47 mL	2.36 mL	4.72 mL
10 mM	0.24 mL	1.18 mL	2.36 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CP 775146

References are publications that support the biological activity of the product.

Kane Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo. Mol.Pharmacol. 2009 PMID: 18971326