CP 99994 dihydrochloride

Name: CP 99994 dihydrochloride
Brand: Tocris Bioscience
SKU: 3417

Tocris Bioscience, part of Bio-Techne | Catalog # 3417

Citations (4)

COA / SDS

High affinity NK1 antagonist

Key Product Details

Description:	High affinity NK₁ antagonist
Chemical Name:	(2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	369.33

View Full Technical Details for CP 99994 dihydrochloride

Technical Data
Citations

Biological Activity for CP 99994 dihydrochloride

CP 99994 dihydrochloride is a high affinity NK₁ antagonist (K_i = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC₅₀ = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 99994 dihydrochloride

CP 99994 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 99994 dihydrochloride

M. Wt	369.33
Formula	C₁₉H₂₄N₂O.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	145148-39-6
PubChem ID	68466923
InChi Key	WNHRFWPLRATIDT-FFUVTKDNSA-N
Smiles	COC(C=CC=C3)=C3CN[C@@H]1[C@H]([C@]2=CC=CC=C2)NCCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 99994 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	36.93	100
	DMSO	18.47	50

Preparing Stock Solutions for CP 99994 dihydrochloride

The following data is based on the product molecular weight 369.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.54 mL	27.08 mL
5 mM	0.54 mL	2.71 mL	5.42 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for CP 99994 dihydrochloride

References are publications that support the biological activity of the product.

Duffy Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther. 2002 PMID: 11961054
Lindstrom Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther. 2007 PMID: 17575073
Shirahase Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK₁ receptors and TXA₂. Br.J.Pharmacol. 1995 PMID: 7582548