CRT 0105950

Name: CRT 0105950
Brand: Tocris Bioscience
SKU: 6273

Tocris Bioscience, part of Bio-Techne | Catalog # 6273

Citations (3)

COA / SDS

Potent LIMK1/2 inhibitor

Key Product Details

Description:	Potent LIMK1/2 inhibitor
Chemical Name:	4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol
Purity:	≥98% (HPLC)
Molecular Weight:	393.89

View Full Technical Details for CRT 0105950

Technical Data
Citations

Biological Activity for CRT 0105950

CRT 0105950 is a potent LIMK1/2 inhibitor (IC₅₀ values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.

Compound Libraries for CRT 0105950

CRT 0105950 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CRT 0105950

M. Wt	393.89
Formula	C₂₁H₁₆ClN₃OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1661845-86-8
PubChem ID	117918970
InChi Key	QYDBOFPHPMYWDO-UHFFFAOYSA-N
Smiles	ClC1=C(C2=CN=CC=C2C3=CN=C(NC4=CC=C(O)C=C4)S3)C=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CRT 0105950

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.39	100
	ethanol	19.69	50

Preparing Stock Solutions for CRT 0105950

The following data is based on the product molecular weight 393.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.69 mL	25.39 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for CRT 0105950

References are publications that support the biological activity of the product.

Mardilovich LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 2015 PMID: 26540348
Charles Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. J.Med.Chem. 2015 PMID: 26356364