CTPI 2

Name: CTPI 2
Brand: Tocris Bioscience
SKU: 7794

Tocris Bioscience, part of Bio-Techne | Catalog # 7794

COA / SDS

Selective mitochondrial citrate transporter (SLC25A1) inhibitor

Key Product Details

Description:	Selective mitochondrial citrate transporter (SLC25A1) inhibitor
Chemical Name:	2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	356.74

View Full Technical Details for CTPI 2

Technical Data
Citations

Biological Activity for CTPI 2

CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a K_D of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.

Technical Data for CTPI 2

M. Wt	356.74
Formula	C₁₃H₉ClN₂O₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	68003-38-3
InChi Key	NJTHPOSQGFJTDP-UHFFFAOYSA-N
Smiles	O=C(O)C=1C=CC=CC1NS(=O)(=O)C2=CC=C(Cl)C(=C2)N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CTPI 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.67	100
	ethanol	7.13	20

Preparing Stock Solutions for CTPI 2

The following data is based on the product molecular weight 356.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.80 mL	14.02 mL	28.03 mL
5 mM	0.56 mL	2.80 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.80 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CTPI 2

References are publications that support the biological activity of the product.

Fernandez The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 2018 PMID: 29651165
Batchuluun Lipogenesis inhibitors: therapeutic opportunities and challenges. Nat.Rev.Drug Discov. 2022 PMID: 35031766
Tan Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020 PMID: 31959914