Cyclothiazide

Name: Cyclothiazide
Brand: Tocris Bioscience
SKU: 0713
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0713

(2)

Citations (217)

COA / SDS

Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization

Key Product Details

Description:	Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
Chemical Name:	6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide
Purity:	≥98% (HPLC)
Molecular Weight:	389.87

View Full Technical Details for Cyclothiazide

Technical Data
Citations / Reviews (2)

Biological Activity for Cyclothiazide

Cyclothiazide is a positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits.

Compound Libraries for Cyclothiazide

Cyclothiazide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Cyclothiazide

M. Wt	389.87
Formula	C₁₄H₁₆ClN₃O₄S₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	2259-96-3
PubChem ID	2910
InChi Key	BOCUKUHCLICSIY-UHFFFAOYSA-N
Smiles	NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C1CC2CC1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclothiazide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.99	100
	ethanol	9.75	25

Preparing Stock Solutions for Cyclothiazide

The following data is based on the product molecular weight 389.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.82 mL	25.65 mL
5 mM	0.51 mL	2.56 mL	5.13 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Reconstitution Calculator

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References for Cyclothiazide

References are publications that support the biological activity of the product.

Donevan and Rogawski Allosteric regulation of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors by thiocyanate and cyclothiazide at a common modulatory site distinct from that of 2,3-benzodiazepines. Neuroscience 1998 PMID: 9758228
Kessler The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits. Neurosci.Lett. 2000 PMID: 10854736
Desai Cyclothiazide acts at a site on the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognise competitive or noncompetitive AMPA receptor antagonists. J.Pharmacol.Exp.Ther. 1995 PMID: 7529311