D-GsMTx4

Name: D-GsMTx4
Brand: Tocris Bioscience
SKU: 7170

Tocris Bioscience, part of Bio-Techne | Catalog # 7170

Citations (4)

COA / SDS

TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion

Key Product Details

Purity:

≥95%

View Full Technical Details for D-GsMTx4

Technical Data
Citations

Biological Activity for D-GsMTx4

D-GsMTx4 is a TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.

Technical Data for D-GsMTx4

Formula	C₁₈₅H₂₇₃N₄₉O₄₅S₆
Storage	Store at -20°C
Purity	≥95%

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D-GsMTx4

Solubility

Soluble Soluble to 1 mg/ml in water

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References for D-GsMTx4

References are publications that support the biological activity of the product.

Bae et al. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4 Biochemistry, 2011;50:6295 PMID: 21696149
Alcaino et al. Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4 Channels (Austin), 2017;11:245 PMID: 28085630
Maneshi et al. Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Sci. Rep., 2018;8:14267 PMID: 30250223
Gnanasambandam et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels Biophys.J., 2017;112:31 PMID: 28076814

D-GsMTx4

Tocris Bioscience, part of Bio-Techne | Catalog # 7170

Key Product Details

Biological Activity for D-GsMTx4

Technical Data for D-GsMTx4

Solubility for D-GsMTx4

Dilution Calculator

Reconstitution Calculator

References for D-GsMTx4

Product Documents for D-GsMTx4

COA

Certificate of Analysis

SDS

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