D-GsMTx4

Name: D-GsMTx4
Brand: Tocris Bioscience
SKU: 7170

Tocris Bioscience, part of Bio-Techne | Catalog # 7170

Citations (4)

COA / SDS

TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion

Key Product Details

Description:	TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
Purity:	≥95% (HPLC)
Molecular Weight:	4095.86

View Full Technical Details for D-GsMTx4

Technical Data
Citations

Biological Activity for D-GsMTx4

D-GsMTx4 is a TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.

Licensing Information

Sold under license from The Research Foundation of The State University of New York

Technical Data for D-GsMTx4

M. Wt	4095.86
Formula	C₁₈₅H₂₇₃N₄₉O₄₅S₆
Single Letter Sequence	GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: All aminoacids = D-aminoacids, Disulfide bridges: 2-17, 9-23, 16-30, Phe-34 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	WVDNTWXIIKNMHY-CFGROZRMSA-N
Smiles	CC(C)C[C@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H]2CSSC[C@@H](NC(=O)CN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]3CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC1=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(N)=O)NC3=O)C(=O)N2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D-GsMTx4

Solubility

Soluble to 1mg/ml in water

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References for D-GsMTx4

References are publications that support the biological activity of the product.

Gnanasambandam GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels Biophys.J. 2017 PMID: 28076814
Alcaino Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4 Channels (Austin) 2017 PMID: 28085630
Maneshi Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Sci. Rep. 2018 PMID: 30250223
Bae The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4 Biochemistry 2011 PMID: 21696149